血管性假血友病因子与冠状动脉病变的关系

Relationship between von Willebrand factor and coronary artery lesion in patients with coronary heart disease

目的研究冠心病患者血管性假血友病因子(vWF)与不同类型冠心病的关系。方法对52例冠心病患者(冠心病组)和16例健康体检者(健康对照组)行vWF测定及冠状动脉造影检查,按冠状动脉造影结果将冠状动脉病变分为A、B、C3型。分析比较2组A、B、C3型间血浆vWF水平的差异,以及血浆vWF与冠状动脉狭窄程度的相关性。结果冠心病组vWF(162±44)%明显高于健康对照组(89±16)%,P<0.01,vWF与冠脉狭窄程度呈显著正相关(r=0.452,P<0.01);C型病变组vWF(194±37)%高于B型病变组(160±39)%,B型病变组高于A型病变组(132±31)%(均为P<0.01)。结论冠心病患者血浆vWF水平与冠脉病变严重程度密切相关。

Objective To investigate the relationship between yon Willebrand factor （vWF） and coronary ar-tery angion in patients with coronary heart disease （CHD） .Methods The vWF was detected and coronary angiograplay were performed in 52 patients with CHD and 16 healthy subjects. CHD patients were divided into 3 groups （type A, B and C） based on the coronary artery lesions. Results The levels of vWF in CHD group were significantly higher than those of control group [ （162±44） % vs （89±16） %, P 〈0.01]. The levels of vWF were positively correlated the severity of coronary lesions （ r =0.452, P 〈0.01）.The plasma vWF levels in group C were significantly higher than those of group B [ （ 194±37） % vs （ 160±39） % ）, P 〈 0.01], but which in group B were obviously hlgher than those in groupA [（160±39）% vs（132±31）%, P 〈0.01].Condusion Thelevels of plasma vWF are closelyrelated with the severity of coronary artery lesion in CHD patients.