基于熵的复杂系统分划方法在冠心病心绞痛中医证候量化诊断标准研究中的应用

Application of Entropy-based Complex Systems Partition Method in Research on Quantizing TCM Syndrome Diagnostic Criteria of Angina Pectoris

目的以基于熵的复杂系统分划方法建立冠心病心绞痛中医证候量化诊断标准。方法将403例冠心病心绞痛患者随机分为运算组(302例)和考核组(101例),以基于熵的复杂系统分划方法提取患者症状信息,确立症状对证候贡献度,以诊断性试验ROC曲线建立诊断阈值。结果冠心病心绞痛可出现络气郁滞、络气虚滞、痰浊、血瘀、火热、痰热、阴虚、阳虚等基本证候,不同症状对证候诊断贡献度不同,并有不同的诊断阈值,经考核组101例患者前瞻性检验,具有良好的灵敏度和特异度。结论基于熵的复杂系统分划方法可用于中医证候量化诊断标准研究,建立的冠心病心绞痛证候量化诊断标准具有良好的诊断效能。

Objective To establish the quantized criteria for TCM syndrome diagnosis of angina pectoris （AP） using the entropy-based complex systems partition method （EBCSPM）. Methods Four hundred and three AP patients were randomly assigned to two groups： the operation group （302 cases） and the examination group （101 cases）. The symptomatic information of the patients was extracted using EBCSPM to make sure the contribution degree of each symptom to syndrome diagnosis, and the diagnostic threshold was established by the analysis of receiver operating characteristic curves （ROC）. Results The basic syndromes manifested during AP were collateral-qi stagnation, collateral-qi deficiency and stagnation, turbid phlegm, blood stasis, phlegm-heat, heat-fire, yin deficiency and yang deficiency, etc. Different symptoms contributed to syndrome diagnosis to different degrees and with different diagnostic thresholds, showing good sensitivity and specificity in the prospective verification on the 101 patients in the examination group. Conclusion EBCSPM is applicable for quantizing TCM diagnostic criteria, and the established criteria shows favorable diagnostic efficacy for TCM syndrome diagnosis of AP.