志苓胶囊治疗400例多种中晚期癌症的疗效观察

Observation on Effects of Zhiling Capsule in Treating 400 Patients with Various Types of Cancer in Mid-Advanced Stage

目的观察志苓胶囊改善多种中晚期癌症患者临床症状及提高生存质量的疗效。方法采用多中心随机对照方法,分别用志苓胶囊(治疗组,300例)和平消胶囊(对照组,100例)治疗,口服2周,观察两组治疗前后临床症状、生活质量、体重增减情况和不良反应。结果治疗组临床症状改善率、生存质量提高率、体重增加率均明显优于对照组(P<0.05);且两组均未见明显不良反应。结论志苓胶囊能明显缓解多种中晚期癌症患者气阴两虚中医证候及痛苦综合征,并能提高患者生存质量。

Objective To observe the efficacy of Zhiling Capsule （ZLC） in improving symptoms and quality of life （QOL） in patients with various types of cancer in mid-advanced stage. Methods A multi-centre randomized and controlled trial was conducted. Four hundred patients with mid-advanced cancer were assigned to two groups： the treatment group （300 cases） treated with ZLC and the control group （100 cases） with Pingxiao Capsule （PXC）, both were given orally for two weeks. Clinical symptoms, QOL, weight and adverse reactions were observed before and after treatment. Results Improving rate of symptom, increasing rates of QOL and weight in the treatment group were all higher than those in the control group （P 〈 0.05） ; and no obvious adverse reaction was observed in the two groups. Conclusion ZLC could alleviate the qi-yin deficiency syndrome and pain syndrome and improve QOL in patients with various types of cancer in mid-advanced stage.