联合检测CEA、CA19-9和CA72-4对结直肠癌诊断的价值

Diagnostic value of combined detection of serum CEA, CA19-9 and CA72-4 in colorectal carcinomas

目的检测结直肠癌患者手术前的血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和肿瘤标记TAG-72(CA72-4)水平,以探讨其对结直肠癌的诊断价值。方法应用电化学发光法检测173例结直肠癌患者和44例结直肠良性疾病患者的CEA、CA19-9和CA72-4水平。结果结直肠癌患者血清CEA、CA19-9和CA72-4含量明显高于良性对照组(P<0.01)。结直肠癌组中三者联合检测CEA+CA19-9+CA72-4阳性率(54.9%)高于CEA+CA72-4(52.6%)、CEA+CA19-9(50.9%)、CA19-9+CA72-4(28.3%)。结论应尽可能同时检测3项指标,以提高其阳性率;若为节约费用,则以CEA+CA72-4组合为好或单测CEA。

Objective To explore the diagnostic value of colorcctal carcinomas by combined detection of the preoperative serum CEA, CA19 - 9 and CA72 - 4. Methods Serum levels of CEA, CA19 - 9 and CA72 - 4 in 173 cases of calorectal carcinomas and 44 cases of benign calorectal diseases were determined by using electro - chemiluminescence immunoassay （ECLIA）. Results The results showed that the serum levels of CEA,CA19 -9 and CA72 -4 were significantly higher in the colorectal carcinoma group than those in the benign colorectal diseases group （ P 〈 0.01）. The positive rate of CEA, CA19 -9 and CA72 -4 in combination was 54.9% , higher than the combination of CEA and CA72 -4 （52. 6% ） ,CEA and CA19 -9 （50.9%）, and CA19 -9 and CA72 -4 （28.3%）. Condusion Appropriate combination of tumor markers may raise positive rates in diagnosing colorectal cancer. For saving money, CEA alone or the combination of CEA and CA72 -4 are the choice of detection.