血清降钙素及相关指标对肺癌诊治的临床意义·

Clinical Significance of Serum Calcitonin and Correlative Tumor Markers in the Diagnosis and Therapy of Lung Cancer

探讨肺癌患者血清降钙素(CT)含量对肺癌诊治的临床意义。用ELISA检测血清CT含量,用电化学发光免疫分析法(ECLIA)检测血清CEA、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片断(CYFRA 21-1)含量。肺癌患者血清CT含量明显高于对照组,化疗前后比较差别有统计学意义(P<0.01),血清CT阳性率与病理分型无关(P>0.05),与临床分期有关(P<0.01)。CT与CEA在肺癌中的阳性表达有差异(P<0.01),与NSE和CYFRA 21-1无差异(P>0.05)。血清CT含量动态监测是辅助诊断肺癌、观察疗效和判断预后的重要指标之一。

To explore the clinical significance of detection of serum calcitonin （CT） levels in patients with lung cancer, serum CT levels were measured by ELISA. The serum levels of CEA, neuron specific enolase（NSE） and CYFRA21-1 were detected by the electro-chemiluminescence immunoassay. The results showed that the mean serum CT level in patients with lung cancer was significantly higher than that in healthy subjects. The serum CT levels were significantly different before and after chemotherapy （P〈0.01）. There was no correlation between the CT positive rate and pathologic tape （P〈0.05）. The CT positive rate was related to the clinical staging （P〈0.01）. The positive results of serum CT in patients with lung cancer were significantly different from positive CEA expression （P〈0.01）, but no difference with serum NSE and CYFRA21-1 （P〉0.05）. The detection of CT levels in serum might have clinical significance in the diagnosis, treatment and predict prognosis of lung cancer.