良性脑膜瘤中PR、VEGF表达及PCNA、Ki-67标记指数与肿瘤复发间的关系

Relationship of expression of PR,VEGF,PCNALI,Ki-67 LI among the tumor recurrence factors in meningiomas

目的 通过对孕激素受体（PR）、血管内皮细胞生长因子（VEGF）表达及肿瘤增殖指标增殖细胞核抗原（PCNA）、Ki-67表达量的分析,探讨上述诸因素与肿瘤复发间的关系。方法 56例脑膜瘤标本分为复发组（n=30）、初发组（n=26）,应用免疫组织化学方法检测其PR、VEGF表达情况,同时检测PCNA、Ki-67的表达量,统计学分析它们与肿瘤复发间的关系。结果 复发组PCNA LI（75±7）%,明显高于初发组（26±7）%;复发组Ki-67 LI（4.0±4.6）%,高于初发组（1.1±1.7）%;PR表达阳性：复发组7例（23.33%）,初发组21例（80.77%）;VEGF表达阳性：复发组13例（43.33%）,初发组9例（34.62%）。结论 PCNA LI、Ki-67及PR表达与脑膜瘤复发有一定的关系,而VEGF表达无统计学意义。

Objective To study clinical significance of PCNALI, Ki - 67, PR, VEGF in predicting the recurrence of meningiomas after tumor removal and relation to the histological features. By detecting the expression of cell proliferating nucler antigen labelling index （ PCNALI ）, Ki - 67 labelling index （ Ki - 67 LI ）, progesterone receptor （ PR ） and vessel endothelium growth factor （VEGF）. Methods Specimens of 56 patients with meningioma were detected for the expression of PCNA, Ki - 67, PR, and VEGF with immunohistochemistry method. The positive expression of PCNA, Ki - 67,PR, VEGF and the interaction between them were statistically analyzed. Results The PCNALI significantly differed in the relapsing group compared to the stable group （P 〈 0. 01 ）. The Ki -67 LI also was higher in the relapsing group than in the stable group （ P 〈0. 05）. In the 30 cases of recurrence meningiomas ,7 cases were positive of PR, 13 cases were positive of VEGF. Conclusion Highter positive expression rate of the PCNALI and Ki -67 LI,lower rate expression of PR, the recurrence of the tumor was increased, VEGF was not correlated with the recurrence of meningiomas. If the meningioma was anaplastic.