异维A酸胶丸治疗结节囊肿性痤疮196例的疗效

Efficacy of isotretinoin capsules for the treatment of nodulocystic acne

目的:观察异维A酸胶丸治疗结节囊肿性痤疮的临床疗效。方法:选择门诊痤疮患者326例进行治疗,随机分成试验组和对照组。试验组196例,口服异维A酸胶丸,剂量0.4mg·kg-1·d-1,bid;对照组130例,口服红霉素12mg·kg-1·d-1,bid。两组均给药12周后观察疗效。结果:试验组有效率显著高于对照组(73.47%vs48·46%,P<0.05)。两组均无明显不良反应发生。结论:异维A酸胶丸治疗结节囊肿性痤疮疗效确切。

Objective： To investigate the therapeutic efficacy of isotretinoin capsules in treatment of nodulocystic acne. Methods： The randomized controlled open-label trail was adopted in the study. Patients diagnosed with nodulocystic acne were randomly divided into isotretinoin capsules group （0. 4 mg.kg^-1 .d^-1 ,bid）and erythromycin group（ 12 mg·kg^-1 ·d^-1 ,bid）. After the treatment for 12 weeks, the therapeutic effects were observed. Results： There was obvious curative effect of isotretinoin in treatment of nodulocystic ache. There was obvious difference between the two groups （P 〈 0.05 ）. Conclusion： For the treatment of nodulocystic acne,the therapeutic efficacy of isotretinoin capsules are definite.