抗心磷脂抗体与脑血管病关系的研究

The study of the relationship between the anticardiolipid antibodies and cerebrovascular disease

目的:探讨抗心磷脂抗体(aCL)与脑血管病(CVD)的关系。方法:检测266例缺血性脑血管病(ICVD)患者和73例脑出血(CH)患者血清aCL。结果:ICVD患者aCL阳性率高于对照组(P<0.01),且IgG型aCL比IgM型aCL阳性率升高(P<0.01)。CH患者aCL阳性率高于对照组(P<0.01)。ICVD组aCL阳性率与CH组比较无显著性差异(P>0.05),ICVD组、CH组和对照组不同性别间aCL阳性率无显著性差异(P>0.05)。结论:aCL可作为CVD危险性增加的指标,对CVD的预测有一定意义,包括ICVD和CH患者,aCL阳性率男女性别之间无差异。

Objective： To study the relation between anticardiolipid antibodies（aCL）and cerebrovascular disease（CVD）. Method： The aCL level was measured in 266 patients with ischemic cerebrovascular disease （ICVD） and 73 patients with cerebral hemorrhage（CH）. Results： The results showed an increased level of aCL was found in patients with CVD . The difference in the aCL patients and controls was very significant （P〈0. 01 ）. The difference in the aCL between ICVD patients and CH patients was not significant （P）0. 05 ）. The level of elevated IgG- aCL were significantly higher than IgM-aCL（P〈 0.01）in patient with ICVD. The difference in the aCL between men and wemen among ICVD patients, CH patients and controls was not significant（P〉0. 05）. Conclusion： AcI. can be regarded as an indicator of an increased severity of CVD and aCL was valuable in stroke predication. Including ICVD patients and CH patients, the difference in the aCL between men and wemen was not significant.