乙型脑炎患儿血清和脑脊液中丙二醛检测的临床意义

Clinical Significance of Malondialdehyde in Serum and Cerebrospinal Fluid in Children with Epidemic Encephalitis B.

目的:探讨流行性乙型脑炎患儿血清及脑脊液中丙二醛(MDA)的变化及临床意义。方法:采用硫代巴比妥酸比色法(TBA)测定48例流行性乙型脑炎患儿血清及脑脊液中MDA含量。结果:极期各型患儿血清及脑脊液中MDA显著增高,其增高程度与病情严重程度呈正相关,恢复期降至正常。结论:血清及脑脊液中MDA水平测定对于判断流行性乙型脑炎患儿脑损伤程度有重要参考价值,可作为估计病情及预后的一项重要指标。

Objectives To study the changes and the significance of malondialdehyde （MDA） in serum and cerebrospinal fluid （CSF） in children with epidemic encephalitis B. Methods Forty-eight children with epidemic encephalitis B were divided into general and se- veretypes, and the contents of MDA were measured in their serum and CSF with thiobarbituric acid （TBA） methods. Results At fastigium period, the serum and CSF contents of MDA in forty-eight children with epidemic encephalitis B were higher than that of the control group. And the increasing degree was consistent with the severity degree of disease. Then the contents of MDA in serum and CSF decreased to normal levels at convalescence. Conclusions The detection of levels of MDA in serum and CSF is helpful to assessing the degree of encephalic lesion. So it can be considered an important marker of assessment of the severity and prognosis of epidemic encephalitis B.