增殖细胞核抗原在估计胆管癌预后的价值探讨

THE PROGNOSTIC SIGNIFICANCE OF PROLIFERATIVE CELL NUCLEAR ANTIGEN PROTEIN IN BILE DUCT CARCINOMA

为探讨增殖细胞核抗原（PCNA）在估计胆管瘤预后中价值，应用免疫组化方法研究胆管癌及其良性病变PCNA蛋白的表达。结果显示：30例胆管癌患者PCNA蛋白阳性表达率为86．7％（26／30），与良性病变组比较有显著性差异（P<0．01），表明癌变组织具有较强的细胞增殖活性。Ⅱ期胆管癌PCNA高增殖组（8例）平均生存期13个月，低增殖组（10例）为26个月，两组有显著性差异（P＜005）。提示PCNA对估计胆管癌预后有一定价值。

To study the prognostic significance of proliferative cell nuclear antigen (PCNA)in bileduct carcinoma,expression of PCNA protein was siudied immunohistochemically in 3 0 pat ients with bileduct carcinoma. Results: 86. 7 percent of bile duct carcinomas showed PCNA POSitive staining and signi-ficiant difference was observed between malignant and benign tissues. These results suggest that proliferative activity of malignant tissues was stronger than that of the benign ones. In patients with cancer ofstages 3,the mean survival time for those with high proliferative activity was 13 months in constrastwith 26 months for those with low activity. PCNA is of prognostic significance for bile duct carcinomapatients.