先天性胆总管扩张症术后对脂溶性维生素吸收的影响

THE STUDY ON THE FAT SOLUBLE VITAMINS ABSORPTIONS AFTER OPERATIVE TREATMENT OF THE CONGENITAL BILIARY DILATATION

为观察先天性胆总管扩张症术后对脂溶性维生素吸收的影响，采用高效液相色谱分析法，对57例术后不同时期患儿和51例正常对照小儿血样进行检测。结果：正常对照组血清维生素A、D、E分别为576.25±170.93ng／ml、13．21±2．20ng／ml及7．34±1．96ng／ml；术后组血清维生素A、D、E分别为501.59±120.64ng／ml、11.66±1.81ng／ml及6.16±1．18ng／ml，明显低于对照组（P<0．01～0．05），但术后10年以上组上述三种维生素值均接近或达到正常水平。说明胆道重建可影响脂溶性维生素吸收，而术后10年以上这些影响逐渐消失。

In order to observe the absorption of the fat soluble vitamins after oPerative treatment ofthe congenital biliary dilatation(CBD),the plasma fat soluble vitamin A,D and E were determined in 57cases of CBD at the postoperative stage and 51 cases of normal children as control. The normal values ofvitamin A,D and E was 576. 25±170. 93ng/ml, 13. 21±2. 20ng/ml and 7.34±1. 96 ng/ml respectivelyin control group versus 501. 59 ± 120. 64ng/ml, 11. 66 ± 1.81ng/ml and 6. 16 ± 1. 18 ng/ml respectivelyin the postoperative group of CBD. The differences were significant for a long period of about 10 years,and gradually disappear after that to approach or near the normal level. There for,the radical operationof CBD may affect the absorption of the fat soluble vitamins.