摘要
目的探讨头孢他啶对体外试验敏感的产CTX-M-14型超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌大鼠肺炎的治疗效果。方法48只大鼠随机分为4组,经鼻内滴入肺炎克雷伯菌菌悬液,制备大鼠肺炎模型;接种细菌后24 h,各组分别给予头孢他啶、哌拉西林/他唑巴坦、头孢噻肟和生理盐水,在各时间点测体温、外周血白细胞总数、中性粒细胞比值,及肺组织匀浆菌落计数。结果治疗72 h后头孢他啶组的各项指标分别与头孢噻肟组或对照组比较差异均有统计学意义(P<0.05);与哌拉西林/他唑巴坦组各项指标比较差异无统计学意义(P>0.05)。结论头孢他啶对体外敏感的产CTX-M-14型ESBLs肺炎克雷伯菌肺炎有较好疗效。
OBJECTIVE To study the therapeutic effect of ceftazidime（CAZ） in a rat model of pneumonia caused by CTX-M-14 extended-spectrum β-1actamases （ESBLs）-producing Klebsiella pneumoniae which is susceptible to ceftazidime in vitro. METHODS Forty eight rats were divided into four groups randomly which were ceftazidimetreated group, piperacillin/tazobactam-treated group, ceftaxime-treated group and the control group. All rats were intranasally inoculated with bacterial suspension of CTX-M-14 ESBLs-producing K. pneumoniae to produce pneumonia models. Twenty four hours after inoculation, rats were intramuscularly administered ceftazidime, piperacillin/tazobactam, ceftaxime, or saline, respectively. The temperature, leucocyte count, percentage of neutrophils, and bacterial counts in the right lungs of rats were detected at some timepoints. RESULTS Compared with the ceftaxime-treated group and the control group, the leucocyte count, percentage of neutrophil count and common logarithm of the bacterial count in the right lungs of the ceftazidime-treated group and piperacillin/ tazobactam-treated group after the treatment which lasted seventy two hours were significantly lower than those of ceftaxime-treated group and the control group （P 〈 0. 05）. There was no difference in the above parameters between the ceftazidime-treated group and piperacillin/tazobactam-treated group （P〉 0. 05）. CONCLUSIONS Ceftazidime shows good therapeutic effect in pneumonia in rats caused by CTX-M-14 ESBLs-producing K. pneurnoniae which is susceptible in vitro.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第9期1064-1067,共4页
Chinese Journal of Nosocomiology
基金
安徽省优秀青年科技基金(200112)
