1株携带6种β-内酰胺酶基因的肺炎克雷伯菌

Discovery of a Klebsiella pneumoniae Strain Carrying Six Kinds of Beta-lactamase Genes

目的了解对亚胺培南敏感的肺炎克雷伯菌(KPN)β-内酰胺酶产生状况。方法对1株KPN用PCR法进行了16种β-内酰胺酶基因(TEM、SHV、LEN、OKP、CTX-M-1群、CTX-M-2群、CTX-M-9群、OXA-1群、OXA-2群、OXA-10群、PER、GES、VEB、CARB、DHA、ACT-1)检测。结果检测显示TEM、SHV、CTX-M-1群、CTX-M-9群、OXA-1群、DHA等6种阳性。结论该株KPN同时携带6种β-内酰胺酶基因。

OBJECTIVE To investigate the generation of beta-lactamases from Klebsiella pneumoniae （KPN） which is only susceptible to imipenem. METHODS Sixteen kinds of beta-lactamase genes were detected in a KPN strain by PCR. The genes included TEM, SHV, LEN, OKP, CTX-M-1 group, CTX-M-2 group, CTX-M-9 group, OXA- 1 group, OXA-2 group, OXA-10 group, PER, GES, VEB, CARB, DHA, and ACT-1. RESULTS The assay showed six positive genes including TEM, SHV, CTX-M-1 group, CTX-M-9 group, OXA-1 group, and DHA. CONCLUSIONS The KPN strain carries six kinds of beta-lactamase genes simultaneously.