北京市部分老年人咽部机会致病菌的携带状况及临床意义

Nasopharyngeal Carriage Status of Opportunistic Pathogens in Old People and Its Significance

目的研究老年人咽部机会致病菌的携带状况及咽部分泌物培养的临床价值。方法对592例老年人进行非感染状态下咽拭子的菌种鉴定。结果老年人咽部检出率较高的机会致病菌,依次为副流感嗜血菌、黏滑口腔球菌、肺炎链球菌、肺炎克雷伯菌;复合菌、肺炎链球菌、肺炎克雷伯菌检出率随年龄增长而升高;合并3种基础疾病受检者中,肺炎克雷伯菌检出率显著高于合并<2种基础疾病的受检者。结论高龄、咽部携带肺炎链球菌、副流感嗜血菌、肺炎克雷伯菌与合并多种基础疾病,可能是老年呼吸道感染性疾病的危险因素。

OBJECTIVE To investigate the nasopharynx carriage status of opportunistic pathogens in non-infectious old people. METHODS The totally of 592 pharyngeal samples from old persons were collected, RESULTS The isolated rates of main opportunistic pathogens were Haemophilus parainfluenzae, Stomatococcus mucilaglnosus, Streptococcus pneumoniae and Klebsiella pneumoniaa. The isolated rate of single opportunistic pathogen was 45.8% and that of multiple opportunistic pathogens was 3.9 %, The total carriage rate of opportunistic pathogen was 49, 7%. The carriage rate of G^＋ or G^- bacteria was 13.2% or 86.8%, respectively. The isolated rates of 2 multiple pathogens, S. pneumoniae and K. pneumoniae were increased with aging. The isolated rate of K. pneumoniae was higher in persons with more than 3 kinds of underlying diseases. CONCLUSIONS Aging, pharyngeal carriaging of S. pneumoniae, H, parainfluenzae, K, pneumoniae, et al and with multiple underlying diseases might be the risk factors for elder people to suffer from infectious respiratory disease. Isolating pharyngeal opportunistic pathogen among non-infection people is necessary and significant for prevention and treatment of infectious respiratory disease.