一种有机镓化合物对小鼠的胚胎毒性和致畸性

EMBRYOTOXICITY AND TERATOGENICITY OF AN ORGANOGALLIUM COMPOUND IN MICE

本文报道２－二甲氨基环己氧基－二甲基镓的胚胎毒性和致畸性的试验结果。雌性小鼠在检出阴栓的当天定为妊娠ｄ０，于ｄ０～ｄ１５每天灌胃一次，剂量分１．５，３，６ｍｇ／ｋｇ三组，对照组给生理盐水，ｄ１７处死小鼠剖腹按常规方法检查胚胎毒性和致畸性。结果表明６ｍｇ／ｋｇ组２只母鼠中毒死亡，各染毒组母鼠体重增长迟缓。３和６ｍｇ／ｋｇ组出现明显胚胎毒性，早期吸收胎明显增加。染毒组活存胎鼠中均有外观、骨骼和内脏畸形可见。

Dimethylaminocyclohexoxy-dimethyl gallium was examined for it`s embryotoxicity and teratogenicity in mice. Female mice, Shanghai strain,on days 6￣15 of pregnancy were given the chemical tested at the dose of 1.5,3 or 6mg/kg per oral intubation once a day. On day 17 dam mice were killed and examined using routine methods for embryotoxicity and teratogenicity.Gain in weight of treated dam mice was retarded.Obvious embryotoxicity was found in groups treated with 3 or 6mg/kg based on significant increase in early absorbtion of embryos.In survived embryos in 3 treatment groups external, skeletal and visceral malformations were observed,however, there was no malformation in control group.