腺苷脱氨酶、乳酸脱氢酶、癌胚抗原、肿瘤抗原19-9、肿瘤抗原125联合检测鉴别良恶性胸腔积液

Benign and malignant pleural effusion differentiated by the combined application of adenosine deaminase,lactate dehydrogenase,carcinoembryonic antigen,cancer antigen 19-9 and cancer antigen 125

目的探讨胸腔积液中腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)、癌胚抗原(CEA)、肿瘤抗原19-9 (CA19-9)、肿瘤抗原125(CA125)联合检测在胸腔积液鉴别诊断中的意义。方法常规采集各80例结核性疾病组和恶性疾病组胸腔积液,测定胸腔积液ADA、LDH、CEA、CA125、CA19-9等五项指标,并进行对比分析。结果联合检测对结核性胸腔积液诊断的敏感度为92.5%、特异度为93.6%、准确度为92.7%;对恶性胸腔积液诊断的敏感度、特异性、准确度分别为92.3%、94.6%、93.5%。结论联合检测多项指标有效地避免了单一指标检测所致的误诊和漏诊,有助于胸腔积液的病因诊断。

Objective To investigate the significance in the differentiation and diagnosis of pleural effusion by detecting adenosine deaminase （ADA）, lactate dehydrogenase （LDH）, carcinoembryonic antigen （CEA）, cancer antigen 19-9（CA19-9） and cancer antigen 125（CA125）. Methods The pleural effusion was routinely collected in 80 patients with tubercular diseases and malignant diseases, the ADA, LDH, CEA, CA125 and CA19-9 in pleural fluid were detected, and then were comparatively analyzed. Results Specificity and accuracy of the combined detection for tubercular pleural effusion were 92.5 %, 93.6 % and 92.7 % respectively, whereas those for malignant pleural effusion were 92.3 % ,94.6 % and 93.5 % respectively. Conclusion The combined detection of several indexes effectively avoids the misdiagnosis and missed diagnosis caused by detection of single index, and it is good to diagnose the causes of pleural effusion.