肿瘤复发患者化疗前后血清中CRP的变化

Serum C-reactive protein in patients with relapse of malignant tumor before and after chemotherapy

目的:初步探讨肿瘤复发患者化疗前后血清中CRP变化的临床意义。方法:利用散射免疫比浊法定量测定患者血清中的CRP值。34例肿瘤复发患者为试验组,22例术后辅助化疗患者设为对照组。结果:83.25%的肿瘤复发患者CRP升高。辅助化疗患者化疗前后的CRP改变不明显;肿瘤复发组化疗有效者的CRP较化疗前明显下降,而化疗无效者较化疗前CRP升高。肿瘤复发组化疗无效者,中位生存时间为8个月。结论:化疗疗效与患者血清CRP变化呈负相关,化疗后CRP升高提示预后不良,CRP可作为肿瘤复发患者的诊断、化疗疗效及预后判断的参考指标。

Objective：To investigate retrospectively the clinical significance the serum C-reactive protein （CRP） in patients with relapse of malignant tumor before and after chemotherapy. Methods：The values of serum CRP were quantitatively determined by immunoephelometry. Thirty-four patients with relapse of malignant tumor were served as the experiment group, and 22 patients with adjuvant chemotherapy after surgical resection were served as control group. Results： CRP elevation was found in 83.25% of patients with relapse of malignant tumor. No obvious change of CRP was found in patients with adjuvant chemotherapy after surgical resection. CRP was decreased in chemotherapy responders after chemotherapy compared to before chemotherapy,but it was increased in chemotherapy nonresponders. Median survival time was 8 months in patients with ineffective chemotherapy. Conclusion：The curative effect was inverse correlation with the CRP level and the increase of CRP after chemotherapy indicates the poor outcome. Maybe CRP could be served as a reference to diagnosis, curative effect and prognosis for patients with relapse of tumor.