美托洛尔片在治疗充血性心衰时的应用

CLINICAL TREATMENT OF CONGESTIVE HEART FAILURE WITH METOPROLOL

β受体阻滞剂多年来被认为是治疗充血性心衰的禁忌药物，近来研究发现它具有上调心脏β受体密度的功能，从而产生β受体介导的正性肌力作用。此组病例我们选择应用洋地黄类药物治疗心衰未能取得明显效果者。从小剂量起加用具有选择性高的β1受体阻滞剂—美托洛尔片治疗充血性心衰，发现加用美托洛尔后对心功能不全的各项体征及症状有明显改善，对心率减慢明显（P＜0．01），对平均动脉压影响小（P＞0．05）。为心衰的治疗开辟了一条新的途径。

β-receptor blocking agent is regarded as taboo drugs of treatment of congestive heart failure for many yeals. Recently many researches showed that it can increase the density of cardiac βl-receptor and bring about the positive inotrpic effect. Among the group observed, it wasn't found obvious effect to use digitalis drugs,however,when used with hy perselective βl-receptor blocking agent-Metoprolol to treat the congestive heart failure. Results showed that Metopro-lol can lower the HR obviously (P<0.01) and it hardly affect mean arterial pressure (P>0.05). It's a new method of treatment of congestive heart failure.