不动杆菌属5年耐药性监测结果分析

A 5-year surveillance study of Acinetobacter species resistance

目的:了解不动杆菌属(包括鲍曼不动杆菌、醋酸钙不动杆菌等)的分离率,监测并分析其对临床常用抗菌药物的耐药性变化。方法:采用API鉴定系统鉴定细菌;K-B纸片扩散法测定抗菌药物敏感性;WHONET5.4软件进行数据分析。结果:2002～2006年不动杆菌的临床分离率逐年上升,由2002年的3.3%上升至2006年的6.8%;不动杆菌对多种常用抗菌药物的耐药率有不同程度的上升,其中耐药率增幅较大的是:阿米卡星21.9%～59.6%、哌拉西林/他唑巴坦25.4%～54.6%、头孢他啶41.5%～69.1%。结论:不动杆菌对多种常用抗菌药物耐药率呈上升趋势,应加强监测;同时对于不动杆菌对阿米卡星、哌拉西林/他唑巴坦和头孢他啶等药物耐药率的快速增长应引起重视,合理选用抗菌药物。

Objective：To study the isolation rate of Acinetobacter species （including Acinetobacter baumannii and Acinetobacter calcoaceticus-baumannii）,survey and analyze the changes of A cinetobacter resistance to common antimicrobial agents. Methods：The bacteria were identified by API system; the sensitivity of antimicrobial agents was tested by K-B method; the data was analyzed by WHONET 5.4. Results：The isolation rate of Acinetobacter was increasing year-by-year from 3.3% in 2002 to 6.8% in 2006; and the resistance rates of Acinetobacter to common antimicrobial agents was increasing. The three of the highest increase as follows： Amikacin from 21.9% to 59.6%,Piperacillin/tazpbactam from 25.4% to 54.6%,Ceftazidime from 41.5% to 69.1%. Conclusion：It＇s important that surveillance data of the resistance rates of Acinetobacter to common antimicrobial agents,place importance on high increases of the resistance rates and select antimicrobial agents rational.