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Notch家族蛋白在肿瘤发生和发展中的作用及分子机制 被引量:1

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摘要 跨膜受体蛋白Notch家族信号通路的活性在决定细胞命运(包括增殖、分化以及凋亡)过程中发挥着重要的作用。经过去十年的研究发现,在急性T淋巴细胞白血病、宫颈癌和乳腺癌等多种人类恶性肿瘤中均有Notch家族蛋白的异常表达,提示Notch与肿瘤的发生发展密切相关。
出处 《中华病理学杂志》 CAS CSCD 北大核心 2007年第9期629-632,共4页 Chinese Journal of Pathology
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