Expression of E-cadherin,beta-catenin,cathepsin D,gelatinases and their inhibitors in invasive ductal breast carcinomas

背景 E-cadherin， beta-catenin，组织蛋白酶 D，矩阵 metalloproteinase (MMP )-2, MMP-9， metalloproteinase (TIMP ) 的织物禁止者 -1 和 TIMP-2 都是侵略相关的蛋白质。在侵略 ductal 胸癌的这些蛋白质的表达式模式，和他们有已知的 clinicopathological 参数，肿瘤复发和雌激素受体的表达式的协会(嗯)，孕酮受体( PR )， PS2 和 c-erbB2 很好没在一套 94 侵略 ductal 胸癌在中国 patients.Methods 被学习，这些分子的标记的蛋白质表达式被 immunohistochemistry ，和他们的协会与已知的 clinicopathological 参数调查， tumo 另外，在这些蛋白质的表情之间的相互关系是保存的 studied.Results 膜 E-cadherin 表示与迟了的肿瘤舞台和肿瘤复发被联系，而减少的 junctional beta-catenin 与积极淋巴节点地位和 c-erbB2 overexpression.Positive 联系了在肿瘤 stromal 组织蛋白酶 D 染色，房间与迟了的肿瘤舞台显示了一个重要协会。在癌症房间的 MMP-2 的高表示与大肿瘤尺寸和 PR 被联系积极表示。TIMP-2 表示断然与肿瘤复发被联系。另外，在这些 biomarkers 的表情之间的相互关系也被估计。在癌症房间染色的组织蛋白酶 D 相反地与它在 stromal 房间染色被相关，并且相反地也相关， MMP-2 在肿瘤 stromal 房间染色。在 stromal 房间的 MMP-2 表示与 TIMP-2 表示显示了反的关联。MMP-9 表示与表示可能精确地具有在更多的一些帮助预言侵略 ductal 胸癌的预后的 E-cadherin， beta-catenin，组织蛋白酶 D， MMP-2 和 TIMP-2 的 TIMP-1 和 TIMP-2 expression.Conclusion 评估显示了平行协会。

Background E-cadhedn, beta-catenin, cathepsin D, matrix metalloproteinase （MMP）-2, MMP-9, tissue inhibitors of metalloproteinase （TIMP）-1 and TIMP-2 are all invasion-related proteins. The expression patterns of these proteins in invasive ductal breast carcinomas, and their associations with known clinicopathological parameters, tumor recurrence and expressions of estrogen receptor （ER）, progesterone receptor （PR）, PS2 and c-erbB2 were not well studied in Chinese patients, Methods In a set of 94 invasive ductal breast carcinomas, protein expressions of these molecular markers were investigated by immunohistochemistry, and their associations with known clinicopathological parameters, tumor recurrence and expressions of ER, PR, PS2 and c-erbB2 were also examined. In addition, the interrelationship between the expressions of these proteins were studied. Results Preserved membrane E-cadherin expression was associated with late tumor stage and tumor recurrence, whereas the reduced junctional beta-catenin associated with positive lymph node status and c-erbB2 overexpression. Positive staining of cathepsin D in tumor stromal cells displayed a significant association with late tumor stage. High expression of MMP-2 in cancer cells was associated with large tumor size and PR positive expression. TIMP-2 expression was positively associated with tumor recurrence. In addition, inter-relationship between the expressions of these biomarkers was also assessed, Cathepsin D staining in cancer cells was inversely correlated with its staining in stromal cells, and also inversely correlated with MMP-2 staining in tumor stromal cells. MMP-2 expression in stromal cells displayed an inverse correlation with TIMP-2 expression. MMP-9 expression displayed parallel associations with TIMP-1 and TIMP-2 expression. Conclusion Evaluation of E-cadherin, beta-catenin, cathepsin D, MMP-2 and TIMP-2 expression may be of some help in more accurately predictinq the pro qnosis of invasive ductal breast carcinomas.