摘要
Multiple myeloma （MM）, a malignancy of clonal plasma cells, is characterized by proliferation and accumulation of abnormal plasmacytes in bone marrow, monoclonal immunoglobulin or its fragment secretions （M-protein） in serum or urine and concomitant extensive osteolytic lesions and/or osteoporosis, anemia, infection or renal dysfunction. The incidence rate of MM has gradually increased in recent years. Traditional chemotherapy results in median survival duration of no more than three years, a 25% five-year survival rate and a ten-year survival rate of less than 5%. It remains an incurable disease and particularly threatens the health of middle-aged and old-aged people.
Multiple myeloma （MM）, a malignancy of clonal plasma cells, is characterized by proliferation and accumulation of abnormal plasmacytes in bone marrow, monoclonal immunoglobulin or its fragment secretions （M-protein） in serum or urine and concomitant extensive osteolytic lesions and/or osteoporosis, anemia, infection or renal dysfunction. The incidence rate of MM has gradually increased in recent years. Traditional chemotherapy results in median survival duration of no more than three years, a 25% five-year survival rate and a ten-year survival rate of less than 5%. It remains an incurable disease and particularly threatens the health of middle-aged and old-aged people.
