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多发性骨髓瘤患者肿瘤坏死因子α水平及其基因启动子多态性的研究 被引量：2

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摘要 多发性骨髓瘤（MM）是以骨髓单克隆浆细胞增多为特征的B细胞恶性疾病，肿瘤B细胞能以自分泌的方式产生TNFα。近年来研究显示口，TNFα基因启动子具有多态性，而这种多态性可能导致TNFα转录水平的变化，可能会影响TNFα在肿瘤增殖过程中的自分泌模式。因此，TNFα基因启动子与人类疾病的关系，成为国内外学者研究热点。
作者 陆紫敏 张全 祖亚钧 孙向华 梁萍
机构地区 同济大学附属同济医院血液科 同济大学生命科学与技术学院
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第9期767-768,共2页 Chinese Journal of Internal Medicine
基金 同济大学同济医院科研基金(TJ0311)
关键词 基因启动子多态性 肿瘤坏死因子Α 多发性骨髓瘤 转录水平 TNFα 浆细胞增多 恶性疾病 分泌模式
分类号 R733.3 [医药卫生—肿瘤]
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共引文献105

同被引文献15

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中华内科杂志
2007年 第9期

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