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慢性移植肾肾病的新型生物标志物 被引量：1

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摘要 近年来肾移植发展迅速，随着新型免疫抑制剂的应用，移植肾的1年存活率大大提高，但远期存活率仍较低。慢性移植肾肾病（CAN）是移植肾远期功能丧失的主要原因之一，而CAN缺乏有效的治疗手段，一旦发展到晚期，则移植肾纤维化难以避免。目前诊断CAN的金标准是肾活检，要早期发现CAN，最有价值的检查手段就是程序性肾活检，但这种定期的创伤性检查患者往往难以接受，也不便于动态监测，并且肾活检的病理结果受活检取材数量与部位的影响，难以标准化，不利于进行随机对照临床试验研究。
作者 陆福明
机构地区 复旦大学附属华山医院肾脏科
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2007年第9期570-571,共2页 Chinese Journal of Organ Transplantation
关键词 慢性移植肾肾病 生物标志物 新型免疫抑制剂 远期存活率 移植肾纤维化 创伤性检查 CAN 肾活检
分类号 R692.9 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

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二级参考文献10

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共引文献5

同被引文献20

  • 1Lazzeri, Elena, Rotondi,et al. High CXCLIO Expression in Rejected Kidneys and Predictive Role of Pretransplant Serum CXCL10 for Acute Rejection And Chronic Allograft Nephropathy. Clinical Transplantation ,2005,79 : 1215 - 1220.
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中华器官移植杂志
2007年 第9期

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