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第11届国际帕金森病和运动障碍大会简讯 被引量:2

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摘要 Neumayer等报道125例PD的患者血浆中α-synuclein(10.3±22.6)ng·mL^-1。50名正常人为(29.4±11.6)ng·mL^-1。因此,提出如果血浆α-synuclein低于12.5ng·mL^-1,提示PD诊断敏感度为83%,特异度为92%。本研究尚未与MSA路易小体阴性的PD作比较。
作者 蒋雨平
出处 《中国临床神经科学》 2007年第5期454-454,共1页 Chinese Journal of Clinical Neurosciences
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  • 4Shi M,Zabetian CP, Hancock AM, et al. Significance and confounders of peripheral DJ-1 and alpha-synucIein in Parkinson's disease[J]. Neurosci Lett,2010 ;480( 1 ) :78-82.
  • 5Barbour R, Kling K, Anderson JP, et al. Red blood cells are the major source of alpha-synuclein in blood [ J]. Neurodegener Dis, 2008 ; 5 ( 2 ) : 55 -9.
  • 6Bosco DA, Fowler DM, Zhang Q,et al. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization[J].Nat Chem Biol,2006;2(5) :249-53.
  • 7Wakabayashi K,Tanji K,Mori F,et al. The Lewy body in Parkinson's disease : molecules implicated in the formation and degradation of alpha-synuclein aggregates [J].Neuropathology,2007 ;27 (5) :494-506.
  • 8El-Agnaf OM, Salem SA, Paleologou KE, et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease[J].FASEB J,2006 ;20 (3) :419-25.
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