第11届国际帕金森病和运动障碍大会简讯
被引量:2
摘要
Neumayer等报道125例PD的患者血浆中α-synuclein(10.3±22.6)ng·mL^-1。50名正常人为(29.4±11.6)ng·mL^-1。因此,提出如果血浆α-synuclein低于12.5ng·mL^-1,提示PD诊断敏感度为83%,特异度为92%。本研究尚未与MSA路易小体阴性的PD作比较。
出处
《中国临床神经科学》
2007年第5期454-454,共1页
Chinese Journal of Clinical Neurosciences
同被引文献13
-
1Jesse S, Steinacker P, Lehnert S, et al. Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes : a review[ J 1. CNS Neurosci Ther,2009 ; 15 (2) : 157-82.
-
2Waragai M,Sekiyama K, Sekigawa A, et al. Alpha-synuclein and D J-1 as potential biological fluid biomarkers for parkinson's disease[J].Int J Mol Sci ,2010 ; 11 ( 11 ) :4257-66.
-
3Lee PH, Lee G, Park HJ, et al. The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy[J].J Neural Transm,2006 ; 113 ( 10 ) : 1435-9.
-
4Shi M,Zabetian CP, Hancock AM, et al. Significance and confounders of peripheral DJ-1 and alpha-synucIein in Parkinson's disease[J]. Neurosci Lett,2010 ;480( 1 ) :78-82.
-
5Barbour R, Kling K, Anderson JP, et al. Red blood cells are the major source of alpha-synuclein in blood [ J]. Neurodegener Dis, 2008 ; 5 ( 2 ) : 55 -9.
-
6Bosco DA, Fowler DM, Zhang Q,et al. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization[J].Nat Chem Biol,2006;2(5) :249-53.
-
7Wakabayashi K,Tanji K,Mori F,et al. The Lewy body in Parkinson's disease : molecules implicated in the formation and degradation of alpha-synuclein aggregates [J].Neuropathology,2007 ;27 (5) :494-506.
-
8El-Agnaf OM, Salem SA, Paleologou KE, et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease[J].FASEB J,2006 ;20 (3) :419-25.
-
9Coelho M, Ferreira JJ. Late-stage Parkinson disease [J ]. Nat Rev Neu- rol,2012,8(8) :435-442.
-
10Stefanis L. alpha-Synuelein in Parkinson's Disease [J]. Cold Spring Harb Perspeet Med,2012,doi: 10.1101/csh- perspect, a009399.
-
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-
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-
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-
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