高同型半胱氨酸血症与多发性硬化的关系初探

Investigation of Hyperhomocysteinemia and Multiple Sclerosis

目的:探讨血清总同型半胱氨酸(tHcy)与多发性硬化(MS)的关系。方法:采用高效液相色谱法检测37例MS患者(MS组)和40名正常对照(NC组)血清中tHcy浓度。结果:MS组和NC组血清中tHcy浓度分别为(23.76±1.659)μmol·L-1、(15.50±1.764)μmol·L-1。MS组tHcy浓度明显高于NC组(P<0.01),而两组叶酸、维生素B12浓度差异无统计学意义(P>0.05);原发进展型、继发进展型和缓解复发型,各型MS组血清tHcy、叶酸、维生素B12水平相比较差异均无统计学意义(P>0.05)。结论:MS患者血清中tHcy水平升高,可能在病理过程中发挥作用。

Aim. To investigate the relationship between hyperhomocysteinemia and multiple sclerosis （MS）. Methods： Fasting serum total homocysteine（tHcy） was determined by high performance liquid chromatograph with 37 MS and 40 normal control （NC）. Results： The mean concentrations of tHcy of MS and NC were （23.76 ± 1.659） μmol·L^-1,（15.50 ± 1.764）μmol·L^-1 respectively. The mean concentration of tHcy of MS is obviously higher than NC （P〈0.01）, while there was no difference about folic acid and vitamin B 12 （P 〉 0.05）. Among subgroups of MS（primary progressive, secondary progressive, relapsing/remitting）, the mean levels of total homocysteine, folic acid and vitamin B12 were no different notably （P 〉 0.05）. Conclusion ： The level of tHcy is higher in MS, hyperhomocysteinemia may contribute to the course of MS.