植物乳杆菌在人体肠道的益生特性

Probiotic properties of Lactobacillus plantarum in the human intestinal tract

植物乳杆菌能够通过胃,并定植于肠道,对人体安全。服用植物乳杆菌后,对健康人群和病患者具有特定的医疗保健作用。同时,植物乳杆菌分泌生物活性分子,激发免疫反应,可作为活疫苗在医学上广泛应用。另外,随着L.plantarum WCFS1全基因组序列的测出,可用分子手段(如启动子筛选、R-IVET、DNA微矩阵)研究肠道微生态系统的机制和探索植物乳杆菌更深层次的益生特性。

L. plantarum has a proven ability to survive gastric transit and colonize the gut, with an apparent safety to the consumer. Many studies describe health promoting effects of consumption of L. plantarum on healthy volunteers and patients. L. plantarum can secrete bioactive molecules that evoke an immune response, therefore as a living vaccine offers a large range of therapeutic possibilities. The availability of the complete genome sequence of L. plantarum WCFS1 makes it a suitable model to study with molecular approaches such as promoter screens, R-IVET, and DNA micro-arrays. This is expected to contribute to unraveling more mechanisms behind the targeted intestinal microbial ecosystem and possible further probiotic properties of L. plantarum.