芳香族化合物的脱芳构化反应

The Dearomatization of Aromatic Compounds

芳香族化合物稳定、易得,通过芳香族化合物的脱芳构化反应,制备官能化的脂肪六元碳环化合物,早已引起人们的广泛兴趣。本文对6类脱芳构化反应进行了逐一评述,包括氧化脱芳构化反应、还原脱芳构化反应、光催化脱芳构化反应、亲核加成脱芳构化反应、σ-键迁移重排脱芳构化反应和过渡金属参与的脱芳构化反应。其中,过渡金属参与的脱芳构化反应,反应条件温和、反应底物广泛,可应用于生物活性物质的合成。

Dearomatization reactions of arenes have been attracted considerable interest because they use stable and widely available materials to provide functionalized alicyclic compounds, which could be employed as synthetic building blocks for synthesis of natural products and bioactive compounds. Over the past four decades, many dearomatization This article reviews six kinds of dearomatization reactions of aromatic compounds including oxidative dearomatization and reduetive dearomatization, photoeatalyzed dearomatization, nueleophilie additive dearomatization, σ-rearrangement dearomatization and transition metals promoted dearomatization. Among them, the transition metals promoted dearomatization proceed under mild reaction conditions with various substrates, and which could be applied for synthesis of bioaetive compounds.