原因不明不育患者减数分裂同源染色体重组的研究

Meiotic Recombination in Unexplained Human Male Infertiliy:An Updated Review

在第一次减数分裂前期,同源染色体之间的重组对同源染色体正确分离起着重要作用。重组异常是染色体不分离的重要风险因子,并可能进一步导致不育。而不育症作为一个重要的健康问题,影响着10%～20%夫妇,其中含有男方因素引起的不育占50%。尽管男性不育的发病率高,但目前关于因减数分裂导致精子发生过程失败的机制仍知之甚少。近年来发展的免疫荧光技术使我们可以直视减数分裂重组事件,为研究人类精子形成的过程提供了新的手段。

During the prophase of meiosis Ⅰ, homologous recombination plays a crucial role in the proper segregation of homologous chromosomes. Altered recombination may be an important risk factor for non-disjunction, which in turn contributes to infertility. Infertility is a major health problem that affects 10%-20% of couples, and about a half is attributed to male factors. Despite the obvious clinical significance of human male infertility, the mechanisms of spermatogenic failure caused by meiotic recombination errors in humans are inadequately known at present. However, recently-developed immunofluorescence methods, which enable us to directly view meiotic recombination events during gametogenesis, have revolutionized our understanding of human spermatogenesis.