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阿扑吗啡与勃起功能障碍 被引量：1

Apomorphine and Erectile Dysfunction
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摘要 ED是男科的常见病之一,其一线治疗方法是口服药物。阿扑吗啡(APO)作为中枢多巴胺受体激动剂,其舌下含片几乎对不同程度的ED患者都有效,且起效快、耐受性好、安全性高,特别是对于接受硝酸盐治疗而禁用西地那非的患者。现对其药代动力学、作用机制及疗效、安全性进行综述。 Erectile dysfunction is a common disease of andrology, for which current guidelines recommend oral agents as the first-line therapy. The dopamine agonist apomorphine acts on the central control of penile erection to allow a sublingual preparation to produce a prompt response. It is not contraindicated in patients on nitrate medication for coronary artery disease. The present review describes the pharmacodynamics, action mechanism, efficacy and adverse effects of apomorphine.
作者 谭大清 姚颐 张杰
机构地区 武汉大学人民医院泌尿外科
出处 《中华男科学杂志》 CAS CSCD 2007年第9期818-821,共4页 National Journal of Andrology
关键词 阿扑吗啡 勃起功能障碍 apomorphine erectile dysfunction
分类号 R698 [医药卫生—泌尿科学]
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参考文献17

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同被引文献14

  • 1陈伟,付小兵,王海滨,周岗,韩冰,李海红,孙同柱,盛志勇.增生性瘢痕中凋亡相关基因转录的变化[J].中华实验外科杂志,2005,22(2):235-237. 被引量：13
  • 2黄宇烽.生精细胞凋亡的基因调控[J].中华男科学杂志,2005,11(9):643-646. 被引量：21
  • 3冷双英,范莉英,陈琼,王更新,赵岩,赵春芳.切除颌下腺对大鼠睾酮和精子顶体酶活力的影响[J].生殖医学杂志,1996,5(3):158-161. 被引量：5
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  • 5Eidson LN,Murphy AZ.Persistent peripheral inflammation attenuates morphine-induced periaqueductal gray glial cell activation and analgesic tolerance in the male rat.J Pain,2013,14(4):393-404.
  • 6Christie MJ.Cellular neuroadaptations to chronic opioids:Tolerance,withdrawal and addiction.Br J Pharmacol,2008,154(2):384-396.
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  • 10王彦华,程万里,刘宇宁,刘惠民,李文斌.Bcl-2和Bax在吗啡依赖雄性大鼠生殖细胞中的表达[J].中国应用生理学杂志,2011,27(1):55-56. 被引量：1

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中华男科学杂志
2007年 第9期

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