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Ca^(2+)在心肌缺血/再灌注损伤的线粒体调控机制中的作用 被引量：2

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摘要 线粒体作为细胞存活和死亡的主宰者发挥多种功能作用,包括氧化-磷酸化作用、自由基生成以及维持细胞内Ca2+平衡。在心肌缺血过程中以及缺血后,线粒体Ca2+浓度升高、功能受损,最终导致细胞坏死或凋亡。本文主要从线粒体Ca2+浓度升高出现的原因、对线粒体功能的病理性调控作用及其诱导的自身保护机制几个方面,综述了Ca2+在心肌缺血/再灌注损伤的线粒体调控机制中的作用。
作者 贾冰 臧伟进
机构地区 西安交通大学医学院药理学系
出处 《心脏杂志》 CAS 2007年第5期596-599,共4页 Chinese Heart Journal
基金 国家重点基础研究发展计划项目资助(No.2007CB512005)
关键词 CA^2+ 线粒体 缺血 再灌注 心肌
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献23

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二级参考文献37

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共引文献30

同被引文献12

  • 1Alberto Dominguez-Rodriguez,Pedro Abreu-Gonzalez,Russel J Reiter.Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era[J].World Journal of Cardiology,2014,6(3):100-106. 被引量：18
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引证文献2

二级引证文献10

心脏杂志
2007年 第5期

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