组蛋白乙酰转移酶/组蛋白去乙酰基酶在慢性阻塞性肺疾病发病机制和治疗中的研究进展

Role of histone acetyltransferases/histone deacetylases in the pathogenesis and therapy of chronic obstructive pulmonary disease

慢性阻塞性肺疾病（COPD）是一种以进展性气流受限为特征的慢性炎症性疾病,病情严重程度与肺部炎症直接相关,多种炎症介质和细胞因子参与其中。组蛋白乙酰转移酶（HAT）与组蛋白去乙酰基酶（HDAC）可通过调节染色质结构而影响炎症基因的表达。HDAC活力降低可抑制核心组蛋白脱乙酰基作用,开启各种炎症基因转录,诱导皮质内固醇抵抗,促进COPD炎症进展和气流受限严重度,从而影响疾病的预后。

Chronic obstructive pulmonary disease （COPD） is a chronic inflammatory disease characterized by progressive airflow limitation. Multiple inflammatory mediators are involved in the lung inflammation,which is directly correlated to the severity of COPD. Histone acetyltransferases （HAT） and histone deacetylases （HDAC） modify the expression of inflammatory genes by regulating chromatin structure. Reduction in HDAC activity accounts for inhibition of histone deacetylation, initiation of inflammatory gene transcription,induction of corticosteroid resistance,and progression of inflammation and airflow limitation in COPD; thus it influences the prognosis of COPD.