摘要
为了解卵巢激素在癫痫发作中所起的作用，本实验采用记录脑电图（ＥＥＧ）同时观察行为的方法，观察了雌二醇（Ｅ２）、孕酮（Ｐ）对马桑内酯（ＣＬ）致痫大鼠行为及皮层、海马ＥＥＧ的影响。结果显示：Ｅ２能缩短ＣＬ致痫大鼠痫性发作及痫波发放的潜伏期，增加痫波发放频率。与之相反，Ｐ具有明显的镇静催眠作用，并延长痫性发作及痫波发放潜伏期，减轻痫性发作程度，减少痫波发放次数。此为雌激素的致痫及孕激素的抗痫作用提供了行为及电生理学证据。本文还对雌、孕激素的基因和非基因作用机制进行了探讨。
To explore the role of ovarian hormones in epilepsy attack,the effect of estradiol(E 2) and progestin(P) on behavior and EEG of the cortex and hippocamus in rats with epilepsy induced by coriaria lactone(CL)were observed by means of EEG recording and simultaneous observation of behavior.The result showed that E 2 could shorten the latencies of epileptic seizure and epileptiform discharges.On the contrary,P had an obvious calmative effect,and could prolong the latencies of epileptic seizure and epileptiform discharge,and reduce seizure degree as well as the number of discharge.These observations provided an electrophysiological evidence in vivo that estrogen could induce epileptic activity and progestin had an anti epilepsy effect.In this paper,the genomic and non genomic mechanisms of ovarian hormnes were also discussed.
基金
国家自然科学基金
