摘要
目的：观察高压氧（HBO）对急性一氧化碳（CO）中毒患者血清心脏肌钙蛋白T（troponinT，TnT）含量变化的影响，并探讨HBO对心肌损伤的疗效及机理。方法：对17例急性CO中毒患者，分别于HBO治疗前和1次治疗后评定Glasgow分数，同时测定血清TnT。对其中6例急性中、重度CO中毒患者在5次HBO治疗后复测血清TnT含量。结果：HBO治疗前后比较，急性轻度CO中毒患者血清TnT含量无显著差异（P＞0．05），急性中、重度CO中毒患者血清TnT含量显著下降（P＜0．05）；而6例急性中、重度CO中毒患者血清TnT含量，在HBO治疗1次、5次后均较治疗前非常明显下降（P＜0．01）。结论：急性中、重度CO中毒均有心肌损伤；HBO治疗可降低血清TnT，表明是治疗急性CO中毒心肌损伤的有效方法。
Aim: To observe the effect of hyperbaric oxygen (HBO) on the change of serum troponin T(TnT) content in patient with acute carbon monoxide (CO) poisoning and to probe the mechanism of the effectiveness of HBO in treating myocardial damage. Methods: The consciousness of 17 patients with acute CO poisoning was assessed with Glasgow Coma Scale (GCS) before and immediately after the 1st time HBO therapy. At the same time, the serum contents of TnT were measured, and which were remeasured after the 5th HBO therapy in 6 acute moderate or severe CO poisoning(GCS 3~ 12) cases. Results: There were no significant differences (P>0. 05) of serum TnT after HBO therapy in acute mild CO poisoning (GCS 13~ 15 ) cases, but significant differences (P<0. 05 ) were present after the 1st time HBO therapy in acute moderate or severe CO poisoning cases. There were very significant differences(P<0. 01) of serum TnT contents in 6 cases of acute moderate or severe CO poisoning after the 1st and 5th time HBO therapy. Conclusion: Myocardial damage was present in all cases of acute moderate or severe CO poisoning. HBO could reduce the contents of serum TnT, which shows it is an effective method in treating myocardial damage due to acute CO poisoning.
