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黄酮类化合物吸收、分布和代谢的研究进展 被引量:35

Advances in studies on absorption,distribution,metabolism of flavonoids
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摘要 各种资料及相关实验表明,黄酮类化合物是一种非常重要的生理活性物质,有着很强的药理活性,是中草药的重要成分。笔者就近几年国内外关于黄酮类化合物的文献资料进行分析、归纳和总结,分别按胃、肠和肝脏几个主要吸收和代谢部位及其在体内的分布情况进行介绍。对于黄酮类化合物的吸收、分布和代谢的研究将为开发黄酮类新药打下坚实的理论基础。 Plenty of data and tests suggested that flavonoids have strong physiological and pharmacological activities. In this paper, the absorption, disrib-ution and metabolism of flavonoids in gaster, gut and liver were introduced. The research of absorption, distribution and metabolism on flavonoids will provide theoretical basis for developing new drugs of flavoniods.
出处 《中国中药杂志》 CAS CSCD 北大核心 2007年第19期1961-1964,共4页 China Journal of Chinese Materia Medica
关键词 黄酮类化合物 吸收 分布 代谢 flavoniods absorption distribution metabolism
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参考文献24

  • 1Lwashina T. The structure and distribution of the flavonoids in plants[J]. J Plant Res, 2000,113:287.
  • 2Crepy V, Morand C, Besson C, et al.Quereetin ,but not its glycolsides, is absorption from the rat stomach [ J ]. J A gric Food Chem, 2002,50(3) :618.
  • 3Taiming L, Xuehuan J. Investation of the absorption mechanisms of baicalin and baicalein in rats[J]. J Pharm Sci, 2006,95(6) : 1326.
  • 4Wen X, WaUe T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability[J]. J Drug Metab Dispos, 2006,34(10) :1786.
  • 5Felgines C, Talavera S. Absorption and metabolism of red orang juice anthocyanins in rats[J]. Br J Nutr, 2006,95 (5) :898.
  • 6Wolffram S, Blockml, Ader P, et al. Quercetin 3-O-beta-glucoside is transported by the glucose carrier SGLT1 across the brush borderrnembrane of rat small intestine[J]. J Nutr, 2002, 132 (3) :630.
  • 7Wilkinson A P, Gee J M, Dupont M S, et al. Hydrolysis by lactaso phlorizin hydrolaso is the first step in the uptake of daidzein glucosides by rat small intestine in vitro [ J ]. J Xenobio-tica, 2003,33(3 ) :255.
  • 8Sesink A L, Arts I C, Faassen-Peters M, et al. Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase[J]. J Nutr, 2003,133(3) :773.
  • 9Jaganath I B, Mullen W, Edwards C A, et al. The relative contribution of the small and large intestine to the absorbtion and metabolism of mtin in man[J]. J Free Radic Res, 2006,40(10) : 1035.
  • 10Hong Cai, David J. Boocock, et al. Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties [ J ]. Cancer Chemother Pharmacol, 2007,60(2 ) :257.

二级参考文献6

  • 1徐庆有,李学信.灯盏细辛注射液对高粘滞血症病人血液粘度的影响[J].新药与临床,1995,14(4):233-234. 被引量:77
  • 2[1]Chen XQ, Jin YY. The New Edition of Medicaments (新编药物学) [M]. 14th Ed. Beijing: People's Medical Publishing House, 1997.277-278.
  • 3[2]Xu QY, Li XX. Influences of Dengzhan Xixin injection on blood viscosity in patients with high blood viscosity [J]. Chin J New Drugs Clin Rem(中国新药与临床杂志), 1995,14(4):233-235.
  • 4[3]Xu JM, Huang ZH. DengZhan XiXin capsules in the treatment of cerebrovascular disorders in 74 patients [J]. Chin J New Drugs Clin Rem(中国新药与临床杂志), 1991,10(5):260-263.
  • 5[4]Department of Chinese Tradititional Medicine and Herbal Drugs, State Drug Administration. Handbook of Active Ingredients of Phytomedicines (植物药有效成分手册) [Z]. Beijing: People's Medical Publishing House, 1986.946-947.
  • 6徐济民,黄震华.灯盏细辛胶囊治疗脑血管疾病74例[J].新药与临床,1991,10(5):260-263. 被引量:13

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