摘要
目的：研究不同O／W型微乳对黄芩苷和葛根素的增溶作用的影响。方法：采用不同油相、乳化剂、助乳化剂及其比例，制成不同配方的微乳，进行理化性质的测定和评价，并对黄芩苷和葛根素在不同溶剂和微乳中的溶解度进行测定。结果：11种微乳配方可形成较好的微乳，各配方对黄芩苷和葛根素均有增溶作用。与水中的溶解度相比，黄芩苷可被增溶5～15倍，葛根素可被增溶3～4倍。结论：微乳对于中药有效成分的增溶具有良好的应用前景。
Objective： To study the effect of O/W Microemulsion in enhancing solubility of haicalin and puerarin. Method： The Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of haicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively. Result： 11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 -4 times than it in water. Conclusion： Microemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第19期1996-1999,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30472195)
关键词
微乳
葛根素
黄芩苷
增溶
microemulsion
solubility
haicalin
puerarin
