摘要
α－氯丙酸制成酰氯，与甘氨酸缩合得α－氯代丙酰甘氨酸，再与二硫化钠反应，经锌粉还原得硫普罗宁．总收率由原工艺的２２．７％提高到２９％（以氯丙酸计）．
α Chloropropionic acid was converted to acid chloride,which was condensed with glycine to give α chloropropionylglycine,and then reacted with sodium disulfide and reduced with zinc powder to obtain tiopronin.The total yield was 29% on the basis of α chloropropionic acid.
出处
《中国药物化学杂志》
CAS
CSCD
1997年第1期55-56,共2页
Chinese Journal of Medicinal Chemistry
