5'-氧-双对甲氧基三苯甲基-α-尿嘧啶核苷的合成新方法

A New Synthesis of 5′O DimethoxytritylαUridine

寡聚α－尿嘧啶核苷酸具有阻止蛋白酶非专一性降解的功能．研究了合成寡聚α－尿嘧啶核苷酸的重要中间体５′－氧－双对甲氧基三苯甲基－α－尿嘧啶核苷的新方法，比文献报道的产率有所提高，由文献的６６％提高到８５％．

α Anomeric oligouridylates are possessed of resistancet to non specific degradation by nucleases.A new method for the preparation of the key intermediate 5′ O dimethoxytrityl α uridine in synthesis of α anomeric oligouridylates was studied in this paper.The yield of the new method was higher than that the literature had reported.