健康医学生志愿者的个性特征

Personality Characteristics of Healthy Volunteers in Pharmacological Research

目的：探讨参加乙酰化酶（ＮＡＴ２）分型试验的健康医学生志愿者的个性特征，为科学地理解和推广以医学生志愿者为被试进行的新药开发和临床药理学研究结果提供依据。方法：采用艾森克个性问卷（ＥＰＱ），对１１９名健康医学生志愿者的个性特征进行测查，并与对照组和全国常模比较。结果：志愿者的精神质（Ｐ）分存在显著的性别差异；志愿者与对照组的个性特征无明显差异；男、女志愿者的Ｐ和Ｌ分均显著低于常模，Ｎ分无明显差异，Ｅ分女性显著高于常模。结论：医学生志愿者的个性特征与一般人群有明显差异。在临床药理学研究中应重视被试者的个性特征及其对实验结果可能造成的影响。

Objective:To examine the personality characteristics of healthy volunteers participated in aNAT2 phenotyping study. Method:119 volunteers and 224 Controls were examined with the Eysenck Personality Questionnaire(EPQ). Results:(1) While significant sex difference in P(Psychoticism) score was found among medical volunteers (P<0.001), no reliable differences were shown between volunteers and controls on any dimension of the personality. (2) as compared to the Chinese age-match norms, there were lower on P and L(Lie) scores in both male and female(P<0.001), higher score on E(Extroversion) in female alone, and no difference on N(neruoticism) in either males or females.Conclusion:Given the results, more attention should be paid to Volunteers personality and the way in which they might alter outcomes of pharmacological research on specific drugs.