血清Ⅲ型前胶原肽在肝纤维化诊断中的意义

The Diagnostic Significance of Serum Procollagen Ⅲ Peptide in Liver Fibrosis

目的:探讨临床肝纤维化的诊断手段。方法:用放射免疫测定法(RIA)检测经肝活检病理确诊的正常人及其它各型慢肝患者共81例血清Ⅲ型前胶原肽(PⅢP)含量,并用维多利亚蓝染色对全部肝活检的肝组织切片进行胶原纤维染色并分级。结果:肝活检纤维化程度与血清 PⅢP含量呈显著正相关(r=0.982,P<0.005)。慢性活动性肝炎(CAH)和肝硬变(LC)患者血清 PⅢP显著高于正常人和慢性迁延性肝炎(CPH)患者(P<0.001)。结论:血清 PⅢP可作为动态观察肝纤维化程度的良好指标,并有助于临床上对慢性肝病进程及预后的判断。

Objective:This paper concerns an approach to diagnosis of liver fibrosis.Methods:Ra- dioimmunoassay was used to detect the level of serum type procollagen peptide(P Ⅲ P)in 81 cases of normal persons and patients with varied liver diseases.The hepatic collagen fibrosis was classified with Victoria blue stain in all liver samples.Results:There was a significant positive correlation between the degree of hepatic fibrosis and the serum P Ⅲ P levels(r=0.982,P<0.005).The serum P Ⅲ P level was significantly elevated in the patients with chronic active hepatitis(CAH),cirrhosis(LC)when com- pared with the healthy subjects and patients with chronic persistent heaptitis(CPH)(P<0.001).Con- clusion:It suggests that serum P Ⅲ P be a good marker for diagnosis of the degree of liver fibrosis and prognosis of liver disease.