家兔再造阴茎神经植入后远期机械感觉纤维再生研究

A long-term study of regeneration of mechanical sensory fibers after free nerve transplantation to the rabbit reconstructed penis

目的 探讨机械感觉纤维在神经植入后的再生情况。方法 用单纤维放电引导技术，从机械感觉传入纤维再生检出率、快慢适应感受器的比例、再生感受器的阈值及再生纤维传导速度等方面，研究了家兔再造阴茎游离神经移植后机械感受器的再生规律。结果 术后9个月再生机械感受纤维数量接近正常水平；快适应机械感受器再生数量多，成熟度较高；慢适应感受器再生数量较少。术后9个月再生纤维传导速度及机械感觉阈值尚未达到正常。结论 家兔再造阴茎游离神经移植后快慢适应机械纤维均有功能恢复，但恢复效果不一致。

Objective To explore the regeneration of mechanical sensory fibers after free nerve transplantation. Method Neuroelectrophysiological technique （single nerve fiber recording） was used to test the regeneration rate of mechanical sensory fibers, the proportion of rapidly and slowly adapting receptors, the stimulating thresholds of regenerated mechanoreceptors and conduction velocity of regenerated fibers.The regeneration pattern of the mechanoreceptors after free nerve transplantation to the rabbit reconstructed penis was also analyzed. Results 9 months after operation, the number of regenerated mechanical sensory fiber was almost normal. The regenerated rapidly adapting receptors had a higher proportion with higher mature degree than the regenerated slowly adapting receptors. 9 months after nerve transplantation the stimulating thresholds of regenerated mechanoreceptors and conduction velocity of regenerated fibers remained below normal. Conclusion After free nerve transplantation to the rabbit reconstructed penis, the function of both rapidly and slowly adapting sensory nerve fiber partially recovered, but in different extent.