幽门螺杆菌感染患者胃氨的变化

Changes of ammonia in gastric juice of patients with Helicobacter pylori infection

目的探讨由Ｈｐ产生的氨在Ｈｐ致病机理中的作用．方法对１６例伴有Ｈｐ感染的消化性溃疡及慢性活动性胃炎患者，应用抗菌素对症治疗４周．分别在治疗前后用尿素酶试剂药盒检查Ｈｐ感染情况，并用Ｎｅｓｌｅｒ′ｓ显色法测定治疗前后的胃液氨浓度．结果治疗后有８例患者Ｈｐ阴转，胃氨浓度由治疗前的３０５７±１９６５μｍｏｌ／Ｌ降至１７６９±９７８μｍｏｌ／Ｌ（Ｐ＜００１），同时胃粘膜病变减轻或治愈．结论氨是Ｈｐ致病的重要因素之一．动态测定胃氨浓度可以间接反映Ｈｐ的感染情况，并可以作为判定治疗效果的一项指标．

AIM To study the clinical significance of ammonia in gastric juice produced by Helicobacter pylori (Hp). METHODS Sixteen peptic ulcer or chronic gastritis patients with Hp infection were treated by antibiotics and other drugs for four weeks. Hp infections were examined by rapid Hp urea test and ammonia concentrations in gastric juice were determined by Nessler′s method before and after the treatment. RESULTS The Hp was converted from positive to negative in 8 of 16 patients, the ammonia concentration in gastric juice of all patients decreased significantly from 305 7±196 5μmol/L to 176 9±97 8μmol/L after treatment. At the same time, the gastric mucosa lesions of all patients were alliviated or cured. CONCLUSION Ammonia produced by Hp is one of the major pathogenic causes of gastric diseases, and the dynamic changes of ammonia concentration in gastric juice can indicate the degree of Hp infection and serve as an index for evaluating the effect of treatment.