乳果糖氢呼吸试验测定口-盲肠传递时间

Measurement of orocecal transit time by lactulose hydrogen breath test

目的测定功能性消化不良（ＦＤ）和肠易激综合征（ＩＢＳ）患者口－盲肠传递时间（ＯＣＴＴ）．方法应用乳果糖氢呼吸试验（ＬＨＢＴ）测定了正常人１３例，ＦＤ２０例和ＩＢＳ（其中１５例主诉腹泻，１６例主诉便秘）３１例患者的ＯＣＴＴ．结果正常人ＯＣＴＴ为９５４±１９６ｍｉｎ，ＦＤ患者（９９２±２４５ｍｉｎ）与正常人比较无显著性差异（Ｐ＞００５），但其中５例动力障碍型ＦＤ的ＯＣＴＴ则显著延长（１２９０±１２０ｍｉｎ，Ｐ＜００１），以便秘为主的ＩＢＳ患者ＯＣＴＴ显著延长（１５４４±５５７ｍｉｎ，Ｐ＜００１），以腹泻为主的ＩＢＳ患者ＯＣＴＴ显著缩短（７３１±２２２ｍｉｎ，Ｐ＜００５）．结论ＦＤ和ＩＢＳ患者存在小肠动力学异常，ＬＨＢＴ可作为辅助检查小肠动力学异常的手段之一．

AIM To investigate the orocecal transit time (OCTT) in patients with FD and IBS. METHODS The OCTT of 13 healthy volunteers, 20 patients with FD and 31 patients with IBS (15 with diarrhoea, 16 with constipation) was measured by lactulose hydrogen breath test (LHBT). RESULTS The OCTT of the FD patients was 99.2±24.5 minutes, similar to that in controls (95 4±19 6minutes, P>0 05), but significantly longer in FD patients with gastroenteric motility disorder (129 0±12 0 minutes, P<0 01). In patients with IBS who complained predominantly of constipation it was significantly longer (154 4±55 7 minutes, P<0 01), but significantly shorter in patients with IBS who suffered predominantly from diarrhoea (73 1±22 2 minutes, P<0 05) than that in controls. CONCLUSION FD and IBS patients have motility disorders of small bowel. LHBT can be used as an essential examination.