序贯式体外反搏对肝脏血流量影响的实验研究

Effects of sequential external counter pulsation on hepatic blood flow in dogs

目的观察实验狗序贯式体外反搏（ＥＣＰ）时肝总动脉和肠系膜上静脉血流量的变化，以探讨ＥＣＰ治疗病毒性肝炎的机理．方法狗１５只，分为ＥＣＰ组１２只，对照组３只．观察ＥＣＰ前、ＥＣＰ３０ｍｉｎ，６０ｍｉｎ和停止ＥＣＰ后３０ｍｉｎ肝总动脉、肠系膜上静脉血流量的变化．对照组狗不使用ＥＣＰ，但观察记录的时间与ＥＣＰ组相同．结果ＥＣＰ组狗在ＥＣＰ３０ｍｉｎ时主动脉收缩压和舒张压均升高，以舒张压升高为明显．于ＥＣＰ６０ｍｉｎ时，主动脉收缩压和舒张压较前下降，以收缩压下降明显（Ｐ＜００１）．在１０只狗身上观察到ＥＣＰ３０ｍｉｎ、６０ｍｉｎ时收缩期和舒张期肝总动脉的血流量比ＥＣＰ前平均增加分别为１４９％和２７０％．其中以舒张期肝总动脉血流量的增加更为显著，ＥＣＰ３０ｍｉｎ为２２５％，ＥＣＰ６０ｍｉｎ为４３８％．结论ＥＣＰ能有效增加肝动脉的血流量，改善肝脏的微循环。

AIM To measure the blood flow of common hepatic artery and superior mesenteric vein in dogs treated with external counter pulsation(ECP). METHODS Fifteen dogs were randomly allocated into two groups, 12 dogs with ECP and 3 without ECP as control. The blood flow in common hepatic artery and superior mesenteric vein was measured before experiment, in 30 and 60 minutes with ECP and 30 minutes after ECP, and in control group without ECP as well.