肝脏孤立性坏死结节的临床病理分析

Clinicopathological study on solitary necrotic nodule of liver

目的探讨肝脏孤立性坏死结节的临床表现、病理形态特征及鉴别诊断要点。方法报告7例肝脏孤立性坏死结节并进行了组织形态学、组织化学研究，结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。结果肝脏孤立性坏死结节由致密的胶原纤维包膜包裹着凝固性坏死物，坏死物中PAS及抗酸染色未检见真菌及结核杆菌。纤维包膜内可见较多淋巴细胞和浆细胞浸润，周围肝组织无异常改变。结论肝脏孤立性坏死结节是一种少见的良性病变，病人局部切除预后好，不复发。

Objective To investigate the clinicopathological features and differential diagnosis of solitary necrotic nodule （SNN） of the liver. Methods Seven patients with liver SNN were enrolled in this study. Based on light microscopic observation, a histochemical study was carried out. The clinical manifestations, pathological features and main point of differential diagnosis were discussed and literature reviewed. Results The liver SNN had a completely necrotic core and a fibrotic capsule. Ziehl-Neelson staining and periodic acid Schiff diastase staining failed to reveal any bacteria or fungi. A sprinkling of monouclear inflammatory cells were present in the wall. The surrounding parenchyma was normal. Conclusion Liver SNN is a rare benign lesion with good progression and without recurrence.