胆管结扎肝硬变犬肝脏血管铸型研究

A cast study of the liver vasculature in cirrhotic dogs

目的研究胆管结扎肝硬变犬肝脏血管形态变化，以探讨肝硬变时肝脏血液循环障碍的类型、程度和意义．方法将正常犬（ｎ＝６）和肝硬变犬（ｎ＝１０）的肝脏取出并处理后，用三种颜色铸型剂分别注入三种血管系统制作出肝血管铸型标本．结果肝硬变犬肝血管铸型主要表现：①门脉主干显著扩张，分支突然中断变细，呈残根状；各级分支形态畸变、走行失常，形成大量吻合支．②肝静脉分支畸变，或被血栓阻塞，或形成吻合支甚至血管瘤．③肝动脉充盈稀少，部分区域呈丛状增生．④肝内广泛门体分流．结论犬胆管结扎肝硬变时，肝内存在严重血管改建、血栓形成和血液循环紊乱．

AIM To explore the state of hepatic vasculature in cirrhosis. METHODS Eighteen mongrel dogs were randomly divided into two groups: six were in control group and the others were subjected to bile_duct_ligation. After 8 weeks, portal hemodynamics and liver histology were estimated in all animals, and then their liver vasculatory casts were made by injections of white, red and blue casting media into portal vein, hepatic artery and vein respectively.