摘要
目的研究中药扶正抗癌冲剂对体外胃癌细胞有无直接抑制或杀伤作用.方法采用体外培养的MKN45,MKN28及SGC7901三种胃癌细胞株,以扶正抗癌冲剂配制药液(1615mg/ml含量)的不同稀释度,对3种胃癌细胞体外作用观察,并设丝裂霉素阳性对照组及单纯培养液加生理盐水阴性对照组.结果扶正抗癌冲剂对3种胃癌细胞株均有一定抑制作用,对低分化MKN45胃癌细胞抑制作用最明显,在1∶2稀释度48h抑制作用最强,抑制率达747%,持续到120h抑制率仍在710%,与正常对照组比较有显著差异(P<005).在电镜下观察被抑制的MKN45胃癌细胞发生线粒体肿胀、内质网水肿、胞浆脂肪空泡样变性、核仁缩小等变化.结论扶正抗癌冲剂对MKN45低分化胃癌细胞有较强的抑制和杀伤作用,并能使胃癌细胞结构改变.
AIM To evaluate the suppressive and killing effects of Fu Zheng anti cancer infusion on gastric cancer cells in vitro. METHODS The suppressive effects of Fu Zheng anti cancer infusion on three gastric cancer cell lines, MKN 45 (poorly differentiated), MKN 28 (highly differentiated) and SGC 7901 were formulated. Mitomycin C suppressive group and culture fluid plus normal saline group served as controls.
关键词
胃肿瘤
癌
中医药疗法
扶正抗癌冲剂
中药品
Stomach neoplasms/zhong yi yao liao fa Antipyretic_detoxicate drugs/therapeutic use Antineoplastic agents (TCD)/therapeutic use\ \ Tumor cells, cultured/drug effects