结直肠癌树突状细胞浸润及癌周淋巴细胞反应与预后的关系

Relationship between infiltration of dendritic cells, pericancerous lymphocytic reaction and prognosis in colorectal carcinomas

目的研究结直肠癌树突状细胞（ＤＣ）浸润和癌周淋巴细胞反应的关系及对预后的影响．方法１９８０年～１９８７年结直肠癌手术７１例，均有随访记录，癌及癌周组织采用Ｓ－１００蛋白抗体ＡＢＣ免疫组化染色，行ＤＣ计数．结果术后生存期≥５年者癌组织ＤＣ数量（５７６７／ｍｍ３±１３３８／ｍｍ３）明显高于＜５年者（３０５９／ｍｍ３±９３１／ｍｍ３）（Ｐ＜００１）．癌周淋巴细胞反应强度和癌组织ＤＣ浸润密度及５年生存率密切相关．结论结直肠癌癌组织ＤＣ浸润密度和癌周淋巴细胞反应强度反映了机体抗肿瘤免疫力，是估计预后的良好指标．

AIM To study the relationship between dendritic cells (DC), pericancerous lymphocytic reaction and the prognosis in colorectal carcinomas. METHODS This study was based on tissues from 71 patients with colorectal carcinomas treated surgically from 1980 to 1987. All patients were followed up for over 5 years. The tumor tissues were examined by ABC immunohistochemical method using S 100 protein antibody and DC was counted.