摘要
目的研究结直肠肿瘤患者血清胃泌素水平与病情的相关性.方法经纤维结肠镜下活组织病理检查和/或术后病理确诊的结直肠腺瘤28例和结直肠癌患者46例,在排除有可能影响血清胃泌素水平的其它情况后,用RIA法检测空腹血清胃泌素及CEA含量.结果以胃泌素≥100ng/L作为结直肠腺瘤的诊断指标,其敏感性、特异性和诊断效率分别为75%,81%和789%,以胃泌素≥130ng/L作为结直肠癌的诊断指标,其敏感性、特异性和诊断效率分别为700%,919%和793%;而CEA≥15μg/L,则分别为320%,944%和485%.以胃泌素≥130ng/L作为癌肿与腺瘤的鉴别诊断指标,其敏感性、特异性和诊断效率都是700%;而CEA≥15μg/L,则分别为300%,900%和486%.在早期结直肠癌患者,胃泌素≥100ng/L者占778%,明显高于便血率(455%).结论血清胃泌素对结直肠肿瘤的诊断和鉴别诊断优于CEA,可作为结直肠癌的普查手段.
AIM To study the diagnostic value of serum gastrin in patients with colorectal neoplasms. METHODS By using radioimmunoassay, the levels of serum gastrin (GAS) and carcinoembryonic antigen (CEA) were measured simultaneously in patients with colorectal cancer ( n =46) and colorectal adenoma ( n =28) diagnosed pathologically. The other circumstances possibly affecting the levels of serum gastrin were excluded.
关键词
结肠肿瘤
直肠肿瘤
胃泌素类
血清
Colorectal neoplasms/blood\ \ Adenoma/blood Gastrins/blood