摘要
目的了解Ｐ５３，ＰＣＮＡ在胃粘膜癌前病变中的表达意义．方法慢性萎缩性胃炎（ＣＡＧ）８９例，慢性浅表性胃炎（ＣＳＧ）２０例和胃腺癌２０例，作ＳＰ法观察Ｐ５３和ＰＣＮＡ的表达．结果Ｐ５３在ＣＳＧ和ＣＡＧ的单纯型、增生型和肠化型中不表达，异型性型中阳性表达率为１９０％（４／２１）．ＰＣＮＡ在ＣＳＧ和ＣＡＧ的单纯型、增生型、肠化型中无显著性差异（Ｐ＞００５）；而ＣＡＧ的异型性阳性细胞明显增多（Ｐ＞００１）．结论Ｐ５３表达与胃粘膜向癌的演变有关．ＰＣＮＡ随细胞增生活跃程度递增．二者结合对胃癌前病变的诊断、分级、治疗、预后有辅助价值．
AIM To investigate the expression significance of P53 and PCNA in precancerous lesions of the stomach. METHODS p53 and PCNA expressions in 89 cases of chronic atrophic gastritis (CAG), 20 chronic superficial gastrtis (CSG) and 20 gastric adenocarcinoma were observed by S P method.
关键词
胃炎
萎缩性胃炎
基因
P53
增殖细胞核抗原
Gastritis, atrophic/metabolism\ \ Genes, p53 Proliferating cell nuclear antigen/metabolism
